| League Record Book | |||||
| Passing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Completions | Jake Delhomme - San Jose | Philadelphia-PHS | 10/3/2010 | San Jose 30-20 | 33 |
| Most Passing Yards | Jon Kitna - Chicago | Seattle | 12/19/2010 | Chicago 30-20 | 392 |
| Best Avg Yards Per Pass | Troy Smith - Hamilton | Southern California | 10/3/2010 | Hamilton 28-24 | 13.1 |
| Longest Completion | Matt Schaub - Philadelphia-PHI | Grand Rapids | 9/19/2010 | Philadelphia-PHI 35-14 | 81 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Completions | San Jose | Philadelphia-PHS | 10/3/2010 | San Jose 30-20 | 33 |
| Most Passing Yards | Chicago | Seattle | 12/19/2010 | Chicago 30-20 | 392 |
| Best Avg Yards Per Pass | Hamilton | Southern California | 10/3/2010 | Hamilton 28-24 | 13.1 |
| Longest Completion | Philadelphia-PHI | Grand Rapids | 9/19/2010 | Philadelphia-PHI 35-14 | 81 |
| Rushing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Carries | Chris D. Johnson - Oklahoma | Hamilton | 11/21/2010 | Oklahoma 27-7 | 37 |
| Most Rushing Yards | Chris D. Johnson - Oklahoma | Philadelphia-PHI | 11/14/2010 | Oklahoma 27-24 | 246 |
| Best Rushing Avg | Jamaal Charles - Green Bay | New York | 12/19/2010 | Green Bay 36-22 | 11.7 |
| Longest Carry | Jamaal Charles - Green Bay | Berlin | 11/21/2010 | Green Bay 21-14 | 80 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Carries | Oakland | Baltimore-BAL | 12/26/2010 | Oakland 41-0 | 55 |
| Most Rushing Yards | Oakland | Baltimore-BAL | 12/26/2010 | Oakland 41-0 | 421 |
| Best Rushing Avg | Montreal | New York | 12/12/2010 | New York 35-34 | 9.3 |
| Longest Carry | Green Bay | Berlin | 11/21/2010 | Green Bay 21-14 | 80 |
| Receiving Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Receptions | Kellen Winslow Jr. - Shreveport | Philadelphia-PHS | 12/12/2010 | Shreveport 42-6 | 20 |
| Most Receiving Yards | Dwayne Bowe - San Jose | Washington | 9/12/2010 | Washington 41-28 | 201 |
| Best Reception Yardage Avg | Deion Branch - Miami | Seattle | 10/10/2010 | Miami 31-24 | 37.4 |
| Longest Reception | James Jones - Philadelphia-PHI | Grand Rapids | 9/19/2010 | Philadelphia-PHI 35-14 | 81 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Receptions | San Jose | Philadelphia-PHS | 10/3/2010 | San Jose 30-20 | 33 |
| Most Receiving Yards | Chicago | Seattle | 12/19/2010 | Chicago 30-20 | 392 |
| Best Reception Yardage Avg | Hamilton | Grand Rapids | 12/26/2010 | Grand Rapids 26-24 | 23.9 |
| Longest Reception | Philadelphia-PHI | Grand Rapids | 9/19/2010 | Philadelphia-PHI 35-14 | 81 |
| Kickoff Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | Ted Ginn Jr. - Philadelphia-PHS | Shreveport | 10/24/2010 | Shreveport 46-35 | 8 |
| Best Return Yardage Avg | Tyjuan Hagler - Tampa Bay | Pittsburgh | 10/17/2010 | Tampa Bay 35-17 | 92.0 |
| Longest Return | Jacoby Ford - Oklahoma | Baltimore-BAC | 10/10/2010 | Baltimore-BAC 34-9 | 100 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | Pittsburgh | St. Louis-STL | 12/5/2010 | St. Louis-STL 36-17 | 9 |
| Best Return Yardage Avg | New Orleans-NOS | Pittsburgh | 11/21/2010 | New Orleans-NOS 41-7 | 90.0 |
| Longest Return | Oklahoma | Baltimore-BAC | 10/10/2010 | Baltimore-BAC 34-9 | 100 |
| Punt Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | Major WrightPR8A - San Francisco | Hamilton | 10/10/2010 | San Francisco 22-0 | 8 |
| Best Return Yardage Avg | Julian Edelman - Baltimore-BAC | New Orleans-NOV | 11/28/2010 | Baltimore-BAC 41-6 | 81.0 |
| Longest Return | Devin Hester - Philadelphia-PHI | Hamilton | 9/12/2010 | Philadelphia-PHI 38-7 | 102 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | San Francisco | Hamilton | 10/10/2010 | San Francisco 22-0 | 8 |
| Best Return Yardage Avg | Baltimore-BAC | New Orleans-NOV | 11/28/2010 | Baltimore-BAC 41-6 | 81.0 |
| Longest Return | Philadelphia-PHI | Hamilton | 9/12/2010 | Philadelphia-PHI 38-7 | 102 |
| Defense Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Tackles | Karlos Dansby - Hamilton | Southern California | 10/3/2010 | Hamilton 28-24 | 17 |
| Sacks | John Abraham - San Francisco | Dallas-DAD | 9/12/2010 | San Francisco 30-27 | 3 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Tackles | Hamilton | Baltimore-BAC | 12/5/2010 | Baltimore-BAC 23-7 | 65 |
| Sacks | Oklahoma | Dallas-DAL | 10/17/2010 | Oklahoma 20-13 | 7 |
| Interception Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Interceptions | Asante Samuel - San Diego | Pittsburgh | 9/26/2010 | San Diego 26-13 | 3 |
| Best Interception Yardage Avg | Sam Shields - Grand Rapids | Seattle | 11/14/2010 | Grand Rapids 34-28 | 93.0 |
| Longest Interception | Sam Shields - Grand Rapids | Seattle | 11/14/2010 | Grand Rapids 34-28 | 93 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Interceptions | Green Bay | New Orleans-NOS | 12/5/2010 | Green Bay 27-10 | 7 |
| Best Interception Yardage Avg | Grand Rapids | Seattle | 11/14/2010 | Grand Rapids 34-28 | 93.0 |
| Longest Interception | Grand Rapids | Seattle | 11/14/2010 | Grand Rapids 34-28 | 93 |