Player_Sacks
| NameFL | TAbb | PosN | Sack | SackYds |
| Charles Johnson | GBP | Left End | 16 | 120 |
| John Abraham | SF4 | Right End | 16 | 103 |
| Ndamukong Suh | OKL | Left Tackle | 14 | 72 |
| Tamba Hali | SEA | Right O LB | 13 | 100 |
| Cameron Wake | SDC | Right O LB | 12 | 91 |
| Jason Babin | PHS | Left End | 12 | 71 |
| Joey Porter | SEA | Right O LB | 10 | 76 |
| Brian Orakpo | OKL | Right O LB | 10 | 74 |
| Justin Tuck | BAC | Left End | 9 | 67 |
| DeMarcus Ware | GBP | Right O LB | 9 | 61 |
| Haloti Ngata | DAL | Right End | 8 | 65 |
| Calvin Pace | PIT | Right O LB | 8 | 50 |
| Kamerion Wimbley | BAC | Left LB | 8 | 45 |
| Kyle Williams | SCS | Nose Tackle | 8 | 34 |
| Jared Allen | BAC | Right End | 7 | 63 |
| James Hall | STL | Right End | 7 | 56 |
| Ahmad Brooks | SF4 | LB | 7 | 54 |
| Stylez White | SDC | Right End | 7 | 52 |
| Lamarr Houston | HAM | Left End | 7 | 43 |
| Larry English | OAK | O LB | 7 | 43 |
| Jonathan Babineaux | PIT | Right Tackle | 7 | 37 |
| Trent Cole | MON | Right End | 6 | 52 |
| Ray Edwards | GBP | Left End | 6 | 36 |
| Matt Shaughnessy | STL | Right End | 6 | 36 |
| Calais Campbell | MIH | Left End | 6 | 36 |
| Chris Long | OAK | Left End | 6 | 32 |
| Will Smith | SLC | Right End | 5 | 47 |
| Clay Matthews | TBB | Left O LB | 5 | 45 |
| Justin Smith | NOV | Right End | 5 | 42 |
| Sedrick Ellis | ATL | Right Tackle | 5 | 40 |
| Fred Robbins | NOV | Left Tackle | 5 | 39 |
| Darnell Dockett | TBB | Right End | 5 | 37 |
| Carlos Dunlap | PHI | Def End | 5 | 33 |
| Cullen Jenkins | SLC | Right End | 5 | 32 |
| Shaun Phillips | SJS | Left O LB | 5 | 31 |
| Julius Peppers | PHI | Right End | 5 | 30 |
| Anthony Adams | TBB | Right Tackle | 5 | 29 |
| Richard Seymour | DAL | Left Tackle | 5 | 17 |
| Casey Hampton | GBP | Nose Tackle | 5 | 8 |
| Antonio Garay | SEA | Nose Tackle | 4 | 37 |
| Nick Eason | SJS | Def End | 4 | 34 |
| Corey Williams | OKL | Right Tackle | 4 | 32 |
| Tommy Kelly | CHE | Right Tackle | 4 | 32 |
| Jason Hunter | OAK | Left O LB | 4 | 32 |
| Mario Williams | ATL | Right End | 4 | 32 |
| Andre Carter | ATL | O LB | 4 | 32 |
| Turk McBride | OKL | Def End | 4 | 31 |
| Phillip Daniels | OKL | Def End | 4 | 30 |
| Chris Clemons | CHE | Left End | 4 | 30 |
| Lorenzo Alexander | SLC | Left O LB | 4 | 29 |
| Robert Geathers | SEA | Left End | 4 | 29 |
| Kyle Vanden Bosch | DAD | Right End | 4 | 27 |
| Jay Ratliff | MIH | Nose Tackle | 4 | 27 |
| Lance Briggs | STL | Right LB | 4 | 26 |
| Robert Mathis | PIT | Left End | 4 | 26 |
| Travis LaBoy | PHI | O LB | 4 | 25 |
| Terrell Suggs | BAC | Right O LB | 4 | 25 |
| Luis Castillo | SCS | Right End | 4 | 23 |
| E.J. Henderson | SDC | Middle LB | 4 | 19 |
| Terrance Knighton | BER | Right Tackle | 4 | 18 |
| B.J. Raji | DAD | Nose Tackle | 4 | 15 |
| Kevin Williams | SJS | Right Tackle | 4 | 11 |
| Amobi Okoye | BAC | Right Tackle | 4 | 10 |
| Tony Brown | NYJ | Right Tackle | 3 | 30 |
| Israel Idonije | SDC | Left End | 3 | 29 |
| Louis Delmas | SF4 | Free Safety | 3 | 26 |
| Colin Cole | DAL | Right Tackle | 3 | 25 |
| Antwan Applewhite | OKL | Right O LB | 3 | 25 |
| Tim Crowder | OAK | Left End | 3 | 23 |
| Juqua Parker | OAK | Left End | 3 | 22 |
| Parys Haralson | MIH | Right O LB | 3 | 22 |
| Aaron Kampman | SHR | Right End | 3 | 22 |
| Alex Brown | MIH | Left End | 3 | 22 |
| Mario Haggan | WAS | Right I LB | 3 | 21 |
| Marcus Benard | GBP | O LB | 3 | 21 |
| James Harrison | STL | Right O LB | 3 | 21 |
| Bryan Thomas | DAL | Left O LB | 3 | 20 |
| Antonio Smith | CHE | Left End | 3 | 19 |
| Adam Carriker | SEA | Left End | 3 | 19 |
| Remi Ayodele | SJS | Left Tackle | 3 | 19 |
| James Farrior | NOS | Left I LB | 3 | 17 |
| Jimmy Kennedy | PHS | Def Tackle | 3 | 17 |
| Scott Fujita | SLC | Right O LB | 3 | 14 |
| Derrick Johnson | CHE | Right I LB | 3 | 14 |
| Lofa Tatupu | GBP | Middle LB | 3 | 13 |
| Ray Lewis | GRR | Left I LB | 3 | 8 |
| Ahtyba Rubin | WAS | Nose Tackle | 3 | 7 |
| Mike Patterson | HAM | Left Tackle | 3 | 6 |
| Aubrayo Franklin | MON | Nose Tackle | 3 | 3 |
| Tommie Harris | SLC | Def Tackle | 3 | 0 |
| Kentwan Balmer | BER | Right End | 2 | 21 |
| Renaldo Hill | PIT | Strong Safety | 2 | 20 |
| Brandon Meriweather | SHR | Free Safety | 2 | 18 |
| Madieu Williams | CHE | Free Safety | 2 | 18 |
| Brandon Graham | BER | Def End | 2 | 17 |
| Osi Umenyiora | GRR | Right End | 2 | 17 |
| Tyson Alualu | CHE | Left Tackle | 2 | 17 |
| Kevin Burnett | NYJ | Right I LB | 2 | 17 |
| Paul Soliai | SDC | Nose Tackle | 2 | 17 |
| Reggie Torbor | SDC | Right O LB | 2 | 16 |
| Arthur Moats | OKL | LB | 2 | 16 |
| Dwight Freeney | PIT | Right End | 2 | 16 |
| C.J. Ah You | TBB | Def End | 2 | 15 |
| Matt Toeaina | ATL | Left Tackle | 2 | 14 |
| Rob Ninkovich | MIH | Left O LB | 2 | 14 |
| Kendall Langford | WAS | Left End | 2 | 14 |
| Glenn Dorsey | WAS | Right End | 2 | 13 |
| O'Brien Schofield | HAM | O LB | 2 | 13 |
| Brodney Pool | SLC | Free Safety | 2 | 13 |
| Sam Shields | GRR | 1st Defensive Back | 2 | 13 |
| Jason Jones | PHS | Left Tackle | 2 | 12 |
| Jacques Cesaire | NOS | Left End | 2 | 12 |
| Mathias Kiwanuka | GRR | O LB | 2 | 12 |
| Deon Grant | MIH | Safety | 2 | 12 |
| Paul Posluszny | PHI | Right I LB | 2 | 12 |
| Brian Urlacher | ATL | Middle LB | 2 | 11 |
| Curtis Lofton | NOS | Middle LB | 2 | 11 |
| Kenyon Coleman | NOS | Left End | 2 | 10 |
| Wallace Gilberry | SF4 | Def End | 2 | 10 |
| Ziggy Hood | DAL | Left End | 2 | 9 |
| Jarret Johnson | WAS | Left O LB | 2 | 9 |
| Dhani Jones | SF4 | Middle LB | 2 | 9 |
| Vince Wilfork | SF4 | Nose Tackle | 2 | 8 |
| Larry Foote | PHS | I LB | 2 | 6 |
| Stephen Cooper | SEA | Left I LB | 2 | 6 |
| Chris Hoke | STL | Nose Tackle | 2 | 3 |
| Bart Scott | PIT | Left I LB | 2 | 3 |
| Marcus Stroud | PHI | Left End | 2 | 2 |
| Daniel Muir | SLC | Left Tackle | 2 | 1 |
| Rolando McClain | SLC | Middle LB | 2 | 1 |
| Sione Pouha | NOS | Nose Tackle | 2 | 0 |
| Gary Brackett | MIH | Middle LB | 2 | 0 |
| David Harris | STL | Right I LB | 2 | 0 |
| Gary Gibson | TBB | Right Tackle | 1 | 12 |
| LaMarr Woodley | SHR | Left O LB | 1 | 12 |
| Sheldon Brown | SF4 | Right CB | 1 | 11 |
| Lawrence Timmons | SF4 | Right I LB | 1 | 11 |
| Brian Cushing | NOV | Left LB | 1 | 10 |
| Sean Jones | PHI | Strong Safety | 1 | 10 |
| Koa Misi | ATL | Left O LB | 1 | 10 |
| John Henderson | PIT | Def Tackle | 1 | 9 |
| Jason Taylor | DAL | O LB | 1 | 9 |
| Nate Allen | SEA | Free Safety | 1 | 8 |
| Rey Maualuga | BAL | Left LB | 1 | 8 |
| Barry Cofield | NOV | Left Tackle | 1 | 8 |
| Corey Webster | PIT | Left CB | 1 | 8 |
| Dan Connor | STL | LB | 1 | 7 |
| Pat Angerer | NOS | Left LB | 1 | 7 |
| Shaun Cody | HAM | Left Tackle | 1 | 7 |
| Manny Lawson | BAL | Left O LB | 1 | 7 |
| Gerald McCoy | GRR | Left Tackle | 1 | 7 |
| Chris Harris | GBP | Free Safety | 1 | 7 |
| Barrett Ruud | SHR | Middle LB | 1 | 7 |
| Keith Bulluck | MON | Left LB | 1 | 6 |
| Brandon Lang | SDC | LB | 1 | 6 |
| Na'il Diggs | SF4 | Left LB | 1 | 6 |
| Danny Clark | PHS | Left LB | 1 | 6 |
| Reshad Jones | OAK | 1st Defensive Back | 1 | 6 |
| Kavell Conner | SJS | Right LB | 1 | 6 |
| D.J. Williams | DAL | Left I LB | 1 | 6 |
| Jacob Ford | SHR | Def End | 1 | 5 |
| Eric Berry | GRR | Strong Safety | 1 | 5 |
| Cody Grimm | SHR | Free Safety | 1 | 5 |
| Mike Wright | DAL | Right End | 1 | 5 |
| Chris Kelsay | BAL | Left O LB | 1 | 4 |
| Jonathan Goff | OAK | Middle LB | 1 | 3 |
| Eric Weddle | BAC | Free Safety | 1 | 3 |
| Will Witherspoon | PIT | Right LB | 1 | 3 |
| James Anderson | NOV | Left LB | 1 | 3 |
| Cam Thomas | BAL | Nose Tackle | 1 | 2 |
| Rocky McIntosh | WAS | Right I LB | 1 | 2 |
| Brandon Mebane | BAC | Left Tackle | 1 | 2 |
| Shaun Rogers | GRR | Nose Tackle | 1 | 2 |
| London Fletcher | NOV | Left I LB | 1 | 0 |
| Kelly Gregg | SHR | Nose Tackle | 1 | 0 |
| Pat Williams | GRR | Left Tackle | 1 | 0 |
| Derek Landri | PIT | Right Tackle | 1 | 0 |
| Desmond Bishop | GBP | Right I LB | 1 | 0 |
| Akeem Jordan | SEA | LB | 1 | 0 |
| Stephen Tulloch | BAC | Middle LB | 1 | 0 |
| Channing Crowder | SJS | Left I LB | 1 | 0 |
| Jerod Mayo | SCS | Left I LB | 1 | 0 |
| Sum | --- | --- | 609 | 3855 |
| Avg | --- | --- | 3 | 21 |