Player_Sacks
| NameFL | TAbb | PosN | Sack | SackYds |
| Jared Allen | SF4 | Right End | 11 | 79 |
| Jason Taylor | PHO | Right End | 10 | 67 |
| David Harris | LAA | Right I LB | 9 | 54 |
| Trent Cole | LAA | Right End | 8 | 57 |
| Shaun Phillips | SDC | Right O LB | 8 | 56 |
| Osi Umenyiora | RED | Right End | 7 | 55 |
| Aaron Kampman | NOV | Left End | 7 | 45 |
| Brodrick Bunkley | SDC | Right Tackle | 7 | 26 |
| Kevin Carter | BUF | Left End | 6 | 53 |
| Patrick Kerney | PIT | Left End | 6 | 44 |
| Shaun Rogers | CAL | Right Tackle | 6 | 37 |
| James Farrior | PEO | Left I LB | 6 | 17 |
| Derrick Johnson | PEO | Left LB | 5 | 41 |
| Julian Peterson | PEO | Right LB | 5 | 39 |
| Derrick Burgess | CHI | Right End | 5 | 31 |
| Nick Barnett | NOV | Middle LB | 5 | 21 |
| Albert Haynesworth | PEO | Right Tackle | 5 | 20 |
| John Lynch | SDC | Free Safety | 4 | 40 |
| Paul Spicer | DAL | Right End | 4 | 33 |
| Elvis Dumervil | SCS | Right End | 4 | 29 |
| Kelly Gregg | PHO | Nose Tackle | 4 | 28 |
| Bryant Young | BUF | Left End | 4 | 25 |
| Darnell Dockett | LAA | Left Tackle | 4 | 24 |
| Calvin Pace | PHO | Left LB | 3 | 26 |
| Shawne Merriman | CHI | Left O LB | 3 | 26 |
| Mario Williams | OAK | Right End | 3 | 21 |
| John Abraham | PEO | Right End | 3 | 19 |
| Antwan Odom | SCS | Left End | 3 | 17 |
| Adewale Ogunleye | PEO | Left End | 3 | 17 |
| James Harrison | NOV | Right O LB | 3 | 15 |
| Adalius Thomas | OAK | Right I LB | 3 | 14 |
| Victor Hobson | OAK | Right O LB | 3 | 12 |
| Kyle Vanden Bosch | RED | Right End | 3 | 12 |
| Ty Warren | NOV | Left End | 2 | 18 |
| Dwan Edwards | DAL | Left End | 2 | 17 |
| Robaire Smith | LAA | Right End | 2 | 17 |
| Gaines Adams | PHO | Right End | 2 | 16 |
| Karlos Dansby | SDC | Right LB | 2 | 16 |
| Will Smith | SDC | Right End | 2 | 16 |
| Marcus Stroud | RED | Left Tackle | 2 | 16 |
| Shaun Ellis | CAL | Left End | 2 | 15 |
| Pat Williams | DAL | Left Tackle | 2 | 15 |
| Michael Strahan | PIT | Left End | 2 | 14 |
| Chris Hovan | CHI | Left Tackle | 2 | 14 |
| Brodney Pool | PHO | Free Safety | 2 | 13 |
| Dunta Robinson | PHO | Left CB | 2 | 13 |
| DeMarcus Ware | RED | Right O LB | 2 | 13 |
| Igor Olshansky | SDC | Left End | 2 | 11 |
| Ray Lewis | CHI | Left I LB | 2 | 11 |
| Dwight Freeney | SCS | Right End | 2 | 10 |
| Terrell Suggs | PHO | Right O LB | 2 | 10 |
| Tommie Harris | LAA | Left Tackle | 2 | 9 |
| Mike Patterson | SEA | Left Tackle | 2 | 9 |
| Dewayne White | LAA | Right End | 2 | 8 |
| Larry Foote | BUF | Right I LB | 2 | 5 |
| Jonathan Babineaux | RED | Right Tackle | 2 | 5 |
| Domonique Foxworth | PHI | 1st Defensive Back | 2 | 4 |
| Grady Jackson | SDC | Def Tackle | 2 | 1 |
| Chris Kelsay | SEA | Left End | 1 | 12 |
| Terrence McGee | OAK | Right CB | 1 | 11 |
| Ed Reed | OAK | Free Safety | 1 | 11 |
| Fred Robbins | OAK | Right Tackle | 1 | 10 |
| Bryan Thomas | SCS | Left O LB | 1 | 9 |
| Adrian Wilson | RED | Strong Safety | 1 | 9 |
| Leon Hall | RED | Left CB | 1 | 9 |
| Justin Tuck | OAK | Def End | 1 | 9 |
| Tanard Jackson | PHI | Free Safety | 1 | 8 |
| Lofa Tatupu | OAK | Middle LB | 1 | 8 |
| Donnie Edwards | DAL | Right LB | 1 | 8 |
| Lance Briggs | SF4 | Right LB | 1 | 8 |
| Roman Harper | PHO | Strong Safety | 1 | 8 |
| Mike Peterson | SDC | Middle LB | 1 | 7 |
| Mike Vrabel | SEA | Left O LB | 1 | 7 |
| Ray Edwards | DAL | Right End | 1 | 7 |
| Keith Brooking | SF4 | Middle LB | 1 | 7 |
| Leroy Hill | RED | Left LB | 1 | 7 |
| Darryl Tapp | SF4 | Right End | 1 | 7 |
| Corey Williams | CAL | Right Tackle | 1 | 6 |
| Joey Porter | SF4 | Left LB | 1 | 6 |
| A.J. Hawk | PIT | Right LB | 1 | 5 |
| Sean Considine | SEA | Strong Safety | 1 | 5 |
| Keith Bulluck | PHI | Right LB | 1 | 5 |
| Walt Harris | CHI | Right CB | 1 | 5 |
| Vince Wilfork | CHI | Nose Tackle | 1 | 5 |
| Casey Hampton | SF4 | Nose Tackle | 1 | 5 |
| Antonio Cromartie | PEO | Right CB | 1 | 5 |
| Tyjuan Hagler | LAA | Left LB | 1 | 4 |
| Travis LaBoy | PHI | Def End | 1 | 4 |
| Chris Canty | CAL | Right End | 1 | 4 |
| Kevin Williams | PHI | Right Tackle | 1 | 3 |
| Bart Scott | PHO | Right I LB | 1 | 2 |
| Jovan Haye | SEA | Right Tackle | 1 | 2 |
| Jamal Williams | SF4 | Nose Tackle | 1 | 1 |
| Patrick Willis | CAL | Right I LB | 1 | 0 |
| E.J. Henderson | PHI | Middle LB | 1 | 0 |
| Cornelius Griffin | OAK | Left Tackle | 1 | 0 |
| Adam Carriker | PHI | Right Tackle | 1 | 0 |
| Chris Hoke | NOV | Nose Tackle | 1 | 0 |
| Barrett Ruud | PEO | Middle LB | 1 | 0 |
| Sum | --- | --- | 261 | 1625 |
| Avg | --- | --- | 3 | 16 |