| Passing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Completions | Drew Brees - Southern California | Los Angeles | 9/10/2006 | Los Angeles 28-27 | 35 |
| Most Passing Yards | Donovan McNabb - Philadelphia | Houston | 9/3/2006 | Philadelphia 38-17 | 467 |
| Best Avg Yards Per Pass | Donovan McNabb - Philadelphia | Houston | 9/3/2006 | Philadelphia 38-17 | 18.0 |
| Longest Completion | Donovan McNabb - Philadelphia | San Francisco | 9/10/2006 | Philadelphia 28-17 | 92 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Completions | Southern California | Los Angeles | 9/10/2006 | Los Angeles 28-27 | 35 |
| Most Passing Yards | Philadelphia | Houston | 9/3/2006 | Philadelphia 38-17 | 467 |
| Best Avg Yards Per Pass | Philadelphia | Houston | 9/3/2006 | Philadelphia 38-17 | 18.0 |
| Longest Completion | Philadelphia | San Francisco | 9/10/2006 | Philadelphia 28-17 | 92 |
| Rushing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Carries | LaDainian Tomlinson - Oakland | Los Angeles | 12/17/2006 | Los Angeles 26-20 | 39 |
| Most Rushing Yards | LaDainian Tomlinson - Oakland | San Francisco | 10/15/2006 | Oakland 42-36 | 265 |
| Best Rushing Avg | Travis Henry - Houston | San Francisco | 12/17/2006 | San Francisco 21-17 | 18.0 |
| Longest Carry | Travis Henry - Houston | San Francisco | 12/17/2006 | San Francisco 21-17 | 89 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Carries | Oakland | California | 9/24/2006 | Oakland 29-10 | 49 |
| Most Rushing Yards | Oakland | California | 9/24/2006 | Oakland 29-10 | 312 |
| Best Rushing Avg | Houston | San Francisco | 12/17/2006 | San Francisco 21-17 | 10.8 |
| Longest Carry | Houston | San Francisco | 12/17/2006 | San Francisco 21-17 | 89 |
| Receiving Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Receptions | Brian Westbrook - Fort Worth | Buffalo | 10/15/2006 | Fort Worth 31-20 | 13 |
| Most Receiving Yards | Steve Smith - St. Louis | California | 9/3/2006 | St. Louis 31-27 | 196 |
| Best Reception Yardage Avg | Steve Smith - St. Louis | California | 9/3/2006 | St. Louis 31-27 | 32.7 |
| Longest Reception | Marques Colston - Philadelphia | San Francisco | 9/10/2006 | Philadelphia 28-17 | 92 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Receptions | Southern California | Los Angeles | 9/10/2006 | Los Angeles 28-27 | 35 |
| Most Receiving Yards | Philadelphia | Houston | 9/3/2006 | Philadelphia 38-17 | 467 |
| Best Reception Yardage Avg | New England | San Francisco | 11/5/2006 | San Francisco 38-24 | 24.0 |
| Longest Reception | Philadelphia | San Francisco | 9/10/2006 | Philadelphia 28-17 | 92 |
| Kickoff Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | Justin Miller - Jersey | California | 10/29/2006 | California 40-17 | 8 |
| Best Return Yardage Avg | Terrence McGee - Oakland | Houston | 10/8/2006 | Oakland 20-13 | 88.0 |
| Longest Return | Josh Cribbs - Southern California | Buffalo | 11/5/2006 | Southern California 16-10 | 99 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | St. Louis | Southern California | 9/24/2006 | Southern California 33-16 | 8 |
| Best Return Yardage Avg | Oakland | Houston | 10/8/2006 | Oakland 20-13 | 88.0 |
| Longest Return | Southern California | Buffalo | 11/5/2006 | Southern California 16-10 | 99 |
| Punt Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | Pacman Jones - California | Buffalo | 12/3/2006 | Buffalo 23-21 | 7 |
| Best Return Yardage Avg | Pacman Jones - California | San Francisco | 11/19/2006 | San Francisco 21-19 | 90.0 |
| Longest Return | Pacman Jones - California | San Francisco | 11/19/2006 | San Francisco 21-19 | 90 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | California | Buffalo | 12/3/2006 | Buffalo 23-21 | 7 |
| Best Return Yardage Avg | California | San Francisco | 11/19/2006 | San Francisco 21-19 | 90.0 |
| Longest Return | California | San Francisco | 11/19/2006 | San Francisco 21-19 | 90 |
| Defense Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Tackles | Al Wilson - California | Houston | 11/26/2006 | Houston 19-17 | 16 |
| Sacks | Dewayne White - Los Angeles | Oakland | 12/17/2006 | Los Angeles 26-20 | 4 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Tackles | California | Houston | 11/26/2006 | Houston 19-17 | 63 |
| Sacks | San Diego | Peoria | 12/17/2006 | San Diego 31-7 | 7 |
| Interception Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Interceptions | Kerry Rhodes - California | Jersey | 10/29/2006 | California 40-17 | 3 |
| Best Interception Yardage Avg | Sammy Knight - New England | San Francisco | 11/5/2006 | San Francisco 38-24 | 88.0 |
| Longest Interception | Sammy Knight - New England | San Francisco | 11/5/2006 | San Francisco 38-24 | 88 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Interceptions | Los Angeles | Philadelphia | 9/17/2006 | Los Angeles 37-24 | 5 |
| Best Interception Yardage Avg | New England | San Francisco | 11/5/2006 | San Francisco 38-24 | 88.0 |
| Longest Interception | New England | San Francisco | 11/5/2006 | San Francisco 38-24 | 88 |