Player_Sacks
| NameFL | TAbb | PosN | Sack | SackYds |
| Julius Peppers | FTW | Left End | 11 | 83 |
| Derrick Burgess | HOU | Right End | 9 | 62 |
| Warren Sapp | LAA | Left Tackle | 9 | 59 |
| Kamerion Wimbley | PHI | Right O LB | 9 | 53 |
| Fred Robbins | OAK | Right Tackle | 9 | 35 |
| Aaron Kampman | NOV | Left End | 7 | 60 |
| Shawne Merriman | HOU | Right O LB | 6 | 49 |
| Leonard Little | FTW | Left End | 6 | 48 |
| Will Smith | SDC | Right End | 6 | 35 |
| Anthony McFarland | OAK | Left Tackle | 6 | 30 |
| Mike Vrabel | FTW | Right O LB | 6 | 25 |
| Dewayne White | LAA | Right End | 5 | 35 |
| Brian Young | SCS | Left Tackle | 5 | 26 |
| Karlos Dansby | SDC | Left LB | 4 | 35 |
| Willie McGinest | NOV | Left O LB | 4 | 32 |
| Tank Johnson | SDC | Right Tackle | 4 | 30 |
| Terrell Suggs | JER | Right End | 4 | 28 |
| Robert Mathis | PEO | Left End | 4 | 27 |
| Luis Castillo | SF4 | Left End | 4 | 25 |
| Cory Redding | OAK | Right Tackle | 4 | 25 |
| Shaun Ellis | CAL | Left End | 4 | 24 |
| Trevor Pryce | PHI | Left End | 4 | 17 |
| Kelly Gregg | JER | Left Tackle | 4 | 9 |
| Antonio Pierce | SCS | Middle LB | 4 | 3 |
| Adewale Ogunleye | PEO | Left End | 3 | 28 |
| Ebenezer Ekuban | SDC | Right End | 3 | 24 |
| Aaron Schobel | HOU | Right End | 3 | 24 |
| Antoine Winfield | JER | Left CB | 3 | 23 |
| Marcus Washington | SCS | Left LB | 3 | 22 |
| Derrick Johnson | PEO | Left LB | 3 | 21 |
| DeMeco Ryans | FTW | Middle LB | 3 | 18 |
| Jason Taylor | JER | Right End | 3 | 18 |
| Bertrand Berry | PHI | Right End | 3 | 17 |
| Adalius Thomas | OAK | Left LB | 3 | 17 |
| Rosevelt Colvin | PIT | Left O LB | 3 | 17 |
| Shaun Phillips | SDC | Left O LB | 3 | 16 |
| Roderick Coleman | SF4 | Right Tackle | 3 | 13 |
| Vonnie Holliday | PIT | Right Tackle | 3 | 13 |
| Junior Seau | LAA | Left I LB | 3 | 10 |
| Pat Williams | NEP | Left Tackle | 3 | 7 |
| Gerald Hayes | SDC | Middle LB | 3 | 6 |
| Tommie Harris | LAA | Left Tackle | 3 | 5 |
| Chris Hoke | NOV | Nose Tackle | 3 | 3 |
| Pisa Tinoisamoa | HOU | Right LB | 2 | 23 |
| Jared Allen | SF4 | Right End | 2 | 21 |
| Darrion Scott | PHI | Left End | 2 | 19 |
| A.J. Hawk | PIT | Right LB | 2 | 18 |
| Marlon McCree | SCS | Free Safety | 2 | 18 |
| Ty Warren | NOV | Left End | 2 | 18 |
| Tommy Kelly | STL | Right Tackle | 2 | 18 |
| Rodney Harrison | SF4 | Strong Safety | 2 | 18 |
| London Fletcher-Baker | HOU | Middle LB | 2 | 17 |
| Robert Geathers | OAK | Def End | 2 | 17 |
| Greg Ellis | BUF | Left O LB | 2 | 16 |
| Chartric Darby | CAL | Left Tackle | 2 | 15 |
| Julian Peterson | PEO | Right LB | 2 | 14 |
| Terence Newman | SDC | Left CB | 2 | 14 |
| Yeremiah Bell | SDC | Strong Safety | 2 | 13 |
| Brandon T. Moore | PHI | Right LB | 2 | 13 |
| Roy Williams | SF4 | Strong Safety | 2 | 13 |
| Dunta Robinson | JER | Left CB | 2 | 12 |
| Bryant Young | BUF | Left End | 2 | 11 |
| Jamal Williams | SF4 | Nose Tackle | 2 | 11 |
| Fakhir Brown | NOV | Right CB | 2 | 11 |
| Brett Keisel | PIT | Right End | 2 | 10 |
| Tedy Bruschi | NEP | Right I LB | 2 | 9 |
| Aaron Smith | PHI | Left End | 2 | 9 |
| John Henderson | FTW | Right Tackle | 2 | 8 |
| Daryl Smith | NOV | Middle LB | 2 | 8 |
| James Farrior | PEO | Left I LB | 2 | 4 |
| Barry Cofield | CAL | Left Tackle | 2 | 0 |
| Keith Brooking | SCS | Right LB | 1 | 12 |
| Kenoy Kennedy | HOU | Strong Safety | 1 | 12 |
| Justin Smith | CAL | Right End | 1 | 11 |
| Chris McAlister | LAA | Left CB | 1 | 11 |
| Stuart Schweigert | NEP | Free Safety | 1 | 11 |
| DeMarcus Ware | STL | Right O LB | 1 | 10 |
| Zach Thomas | SF4 | Middle LB | 1 | 8 |
| Troy Polamalu | SCS | Strong Safety | 1 | 8 |
| Charles Grant | STL | Left End | 1 | 8 |
| Joey Porter | SF4 | Right O LB | 1 | 8 |
| Ty Law | HOU | Left CB | 1 | 8 |
| Chris Hovan | HOU | Left Tackle | 1 | 8 |
| Kelvin Hayden | PEO | 1st Defensive Back | 1 | 8 |
| Mario Williams | OAK | Right End | 1 | 7 |
| Marcus Trufant | OAK | Right CB | 1 | 7 |
| Hunter Hillenmeyer | LAA | Left LB | 1 | 7 |
| Keith Traylor | NEP | Left Tackle | 1 | 7 |
| Keith Bulluck | PHI | Right LB | 1 | 7 |
| Channing Crowder | FTW | Right LB | 1 | 7 |
| Kevin Carter | BUF | Left End | 1 | 7 |
| Dawan Landry | FTW | Strong Safety | 1 | 7 |
| Manny Lawson | OAK | Left LB | 1 | 7 |
| Kenard Lang | JER | Left End | 1 | 6 |
| Donte Whitner | SDC | Strong Safety | 1 | 6 |
| Greg Spires | LAA | Left End | 1 | 6 |
| Dwight Freeney | SCS | Right End | 1 | 6 |
| Greg Wesley | JER | Free Safety | 1 | 6 |
| Clark Haggans | SF4 | Left O LB | 1 | 5 |
| Ryan Pickett | BUF | Right Tackle | 1 | 5 |
| Lance Briggs | SF4 | Right LB | 1 | 4 |
| Richard Seymour | NEP | Right End | 1 | 3 |
| Atari Bigby | PEO | 1st Defensive Back | 1 | 3 |
| Kendrick Clancy | PEO | Left Tackle | 1 | 1 |
| Jeremiah Trotter | PIT | Middle LB | 1 | 1 |
| Michael Myers | SCS | Left Tackle | 1 | 0 |
| Grady Jackson | SDC | Left Tackle | 1 | 0 |
| Vince Wilfork | HOU | Nose Tackle | 1 | 0 |
| Nick Barnett | NOV | Middle LB | 1 | 0 |
| La'Roi Glover | NOV | Left Tackle | 1 | 0 |
| Larry Foote | BUF | Right I LB | 1 | 0 |
| Sum | --- | --- | 291 | 1773 |
| Avg | --- | --- | 3 | 16 |