Player_Sacks
| NameFL | TAbb | PosN | Sack | SackYds |
| Will Smith | NJG | Right End | 15 | 103 |
| Trent Cole | SDC | Left End | 13 | 89 |
| Richard Seymour | SDC | Right End | 13 | 87 |
| Darwin Walker | HAM | Right Tackle | 12 | 56 |
| Warren Sapp | SCO | Left Tackle | 11 | 78 |
| Vonnie Holliday | PHO | Right Tackle | 10 | 53 |
| Kevin Carter | LVG | Left End | 9 | 73 |
| Bart Scott | PIT | Right LB | 9 | 63 |
| Aaron Schobel | GRR | Right End | 9 | 61 |
| Mark Anderson | PHI | Def End | 8 | 62 |
| John Abraham | SFF | Right End | 8 | 55 |
| Derrick Burgess | NYJ | Right End | 8 | 47 |
| Dwight Freeney | BER | Right End | 7 | 63 |
| Adewale Ogunleye | CHI | Left End | 7 | 61 |
| Bobby McCray | PIT | Left End | 7 | 53 |
| Hollis Thomas | SDC | Right Tackle | 7 | 44 |
| Jason Taylor | STL | Right End | 7 | 41 |
| Trevor Pryce | SCS | Left End | 7 | 35 |
| Ryan Denney | NYG | Def End | 6 | 47 |
| Robert Mathis | PIT | Left End | 6 | 44 |
| Brian Dawkins | GRR | Free Safety | 6 | 39 |
| Leonard Little | SHR | Left End | 6 | 38 |
| Shawne Merriman | MON | Right O LB | 6 | 37 |
| Kyle Vanden Bosch | PHO | Left End | 6 | 34 |
| Roderick Coleman | SHR | Right Tackle | 5 | 42 |
| A.J. Hawk | PIT | Right LB | 5 | 41 |
| Bertrand Berry | NYJ | Right End | 5 | 40 |
| Darren Howard | HAM | Right End | 5 | 36 |
| Takeo Spikes | NOV | Right LB | 5 | 36 |
| Shaun Phillips | SJS | Left O LB | 5 | 36 |
| Justin Smith | NJG | Right End | 5 | 35 |
| Phillip Daniels | TBB | Left End | 5 | 34 |
| Ebenezer Ekuban | SCS | Right End | 5 | 31 |
| Bryant Young | SDC | Left End | 5 | 30 |
| La'Roi Glover | SJS | Left Tackle | 5 | 29 |
| Chike Okeafor | FTW | Left End | 5 | 29 |
| John Henderson | PIT | Right Tackle | 5 | 29 |
| Jonathan Babineaux | PIT | Def Tackle | 5 | 24 |
| Jared Allen | BAC | Right End | 5 | 24 |
| Mike Vrabel | BER | Right O LB | 5 | 18 |
| Shelton Quarles | TBB | Middle LB | 5 | 18 |
| Michael Myers | LVG | Left Tackle | 5 | 14 |
| Lofa Tatupu | GBP | Middle LB | 5 | 7 |
| Kabeer Gbaja-Biamila | LVG | Right End | 4 | 32 |
| Aaron Kampman | NOV | Left End | 4 | 30 |
| Dewayne White | TBB | Right End | 4 | 29 |
| Keith Traylor | PHS | Left Tackle | 4 | 29 |
| Terrence Holt | PHS | Free Safety | 4 | 27 |
| DeMarcus Ware | SCO | Right O LB | 4 | 27 |
| Kawika Mitchell | PIT | Middle LB | 4 | 25 |
| Cory Redding | BAL | Right Tackle | 4 | 25 |
| Gerard Warren | BER | Right Tackle | 4 | 23 |
| Junior Seau | PHI | Left I LB | 4 | 21 |
| Derrick Johnson | NJG | Left LB | 4 | 20 |
| Sam Adams | CHI | Left Tackle | 4 | 16 |
| Kevin Williams | SJS | Right Tackle | 4 | 14 |
| Nick Barnett | NYJ | Middle LB | 4 | 13 |
| Ken Hamlin | SDC | Free Safety | 3 | 27 |
| Brandon Chillar | PHS | Left LB | 3 | 27 |
| Patrick Kerney | MON | Left End | 3 | 26 |
| Julius Peppers | PHI | Left End | 3 | 25 |
| Jason Hatcher | OAK | Def End | 3 | 23 |
| Lance Briggs | STL | Right LB | 3 | 22 |
| Elvis Dumervil | HAM | Def End | 3 | 22 |
| Ty Warren | DAL | Left End | 3 | 21 |
| Rosevelt Colvin | TBB | Left O LB | 3 | 20 |
| Osi Umenyiora | GRR | Right End | 3 | 19 |
| James Harrison | STL | O LB | 3 | 18 |
| Julian Peterson | NYG | Right LB | 3 | 17 |
| Will A. Allen | NJG | Free Safety | 3 | 17 |
| Albert Haynesworth | BER | Right Tackle | 3 | 17 |
| Adalius Thomas | CHI | Left LB | 3 | 16 |
| Chris Draft | NJG | Middle LB | 3 | 15 |
| Erik Coleman | NYJ | Strong Safety | 3 | 14 |
| C.C. Brown | OAK | Free Safety | 3 | 14 |
| Brian Russell | LVG | Free Safety | 3 | 13 |
| Tommie Harris | NJG | Left Tackle | 3 | 13 |
| Brian Young | SCO | Left Tackle | 3 | 10 |
| Travis Johnson | BUF | Left Tackle | 3 | 5 |
| Derek Smith | SJS | Middle LB | 3 | 3 |
| Kamerion Wimbley | NYJ | Right O LB | 2 | 21 |
| Shaun Ellis | BER | Left End | 2 | 21 |
| Luis Castillo | GBP | Left End | 2 | 21 |
| Scott Shanle | GRR | Right LB | 2 | 21 |
| Tank Johnson | PHI | Right Tackle | 2 | 18 |
| Greg Ellis | SFF | Left O LB | 2 | 17 |
| Bryan Robinson | DAL | Left End | 2 | 17 |
| Terrell Suggs | BAC | Right End | 2 | 17 |
| Karlos Dansby | HAM | Left LB | 2 | 16 |
| Clark Haggans | BER | Left O LB | 2 | 15 |
| Alex Brown | BUF | Right End | 2 | 15 |
| Mario Williams | MIN | Right End | 2 | 15 |
| Angelo Crowell | DAL | Left LB | 2 | 14 |
| Cato June | SDC | Right LB | 2 | 14 |
| Michael Boley | BER | Left LB | 2 | 14 |
| Darryl Tapp | NOV | Def End | 2 | 14 |
| Jason David | SCS | Right CB | 2 | 14 |
| Ernie Sims | HAM | Right LB | 2 | 14 |
| Tamba Hali | STL | Left End | 2 | 14 |
| Aaron Smith | SHR | Left End | 2 | 14 |
| Michael Strahan | SFF | Left End | 2 | 14 |
| Bryan Thomas | NYG | Right O LB | 2 | 13 |
| Roy Williams | STL | Strong Safety | 2 | 13 |
| Tyrone Poole | PIT | 1st Defensive Back | 2 | 13 |
| Chartric Darby | MIN | Left Tackle | 2 | 11 |
| Rob Meier | OAK | Def Tackle | 2 | 11 |
| Cornelius Griffin | FTW | Left Tackle | 2 | 11 |
| Charles Grant | MON | Left End | 2 | 11 |
| Pat Williams | GRR | Left Tackle | 2 | 11 |
| Grant Wistrom | PIT | Right End | 2 | 11 |
| Bryce Fisher | PHS | Left End | 2 | 10 |
| Stephen Cooper | LVG | I LB | 2 | 9 |
| Daryl Smith | STL | Middle LB | 2 | 7 |
| Deon Grant | PHO | Free Safety | 2 | 7 |
| London Fletcher-Baker | NOV | Middle LB | 2 | 7 |
| Larry Foote | MON | Right I LB | 2 | 6 |
| Hunter Hillenmeyer | NYJ | Left LB | 2 | 6 |
| Kris Jenkins | NJG | Right Tackle | 2 | 5 |
| Darnell Dockett | TBB | Right Tackle | 2 | 4 |
| Mark Simoneau | SCS | Middle LB | 2 | 2 |
| Vince Wilfork | SFF | Nose Tackle | 2 | 1 |
| Donnie Edwards | BAC | Right I LB | 2 | 1 |
| Zach Thomas | CHI | Middle LB | 2 | 1 |
| Antonio Pierce | OAK | Middle LB | 2 | 0 |
| Ryan Pickett | BAC | Right Tackle | 2 | 0 |
| Greg Spires | BAL | Left End | 1 | 12 |
| Eric Barton | PHO | Left O LB | 1 | 12 |
| Mike Minter | NYG | Free Safety | 1 | 11 |
| Bob Sanders | PHI | Free Safety | 1 | 11 |
| Brady Poppinga | BAC | Left LB | 1 | 11 |
| Keith Brooking | SCO | Right LB | 1 | 10 |
| Kevin Bentley | SCS | LB | 1 | 10 |
| Fred Smoot | SFF | 1st Defensive Back | 1 | 10 |
| Abdul Hodge | TBB | LB | 1 | 10 |
| DeMeco Ryans | FTW | Middle LB | 1 | 10 |
| Tommy Kelly | SHR | Right Tackle | 1 | 9 |
| E.J. Henderson | SDC | Right LB | 1 | 9 |
| Victor Hobson | SFF | Right I LB | 1 | 9 |
| Jason Babin | SFF | Def End | 1 | 9 |
| Marcus Washington | FTW | Left LB | 1 | 9 |
| Robert Geathers | BUF | Def End | 1 | 9 |
| Demorrio Williams | FTW | LB | 1 | 8 |
| Donte Whitner | NJG | Strong Safety | 1 | 8 |
| Carlos Rogers | GRR | Right CB | 1 | 8 |
| Thomas Davis | SHR | Left LB | 1 | 8 |
| Marques Douglas | DAL | Right Tackle | 1 | 8 |
| Nick Greisen | BUF | Right LB | 1 | 7 |
| Barry Cofield | NOV | Left Tackle | 1 | 7 |
| Scott Fujita | NJG | Left LB | 1 | 7 |
| Will Demps | FTW | Free Safety | 1 | 7 |
| Daven Holly | FTW | Right CB | 1 | 7 |
| Channing Crowder | SJS | Right LB | 1 | 7 |
| Darren Sharper | SHR | Strong Safety | 1 | 7 |
| Mike Patterson | DAL | Left Tackle | 1 | 7 |
| Andra Davis | MON | Left I LB | 1 | 7 |
| Jarrad Page | NYJ | 1st Defensive Back | 1 | 7 |
| Pisa Tinoisamoa | MIN | Right LB | 1 | 6 |
| Chauncey Davis | NYG | Def End | 1 | 6 |
| Omar Gaither | LVG | Right LB | 1 | 6 |
| Fakhir Brown | SHR | Right CB | 1 | 6 |
| Dunta Robinson | NOV | Left CB | 1 | 5 |
| Dexter Jackson | PIT | Strong Safety | 1 | 5 |
| Ian Scott | FTW | Def Tackle | 1 | 5 |
| Chris Hovan | OAK | Left Tackle | 1 | 5 |
| Terdell Sands | GRR | Def Tackle | 1 | 5 |
| Gibril Wilson | GRR | Strong Safety | 1 | 4 |
| Matt McCoy | PHI | LB | 1 | 4 |
| Gary Brackett | BUF | Middle LB | 1 | 4 |
| D'Qwell Jackson | STL | Right I LB | 1 | 4 |
| Willie McGinest | PHS | Left O LB | 1 | 4 |
| Al Wilson | SFF | Middle LB | 1 | 3 |
| Rodney Leisle | BUF | Def Tackle | 1 | 3 |
| Jarvis Green | DAL | Def End | 1 | 3 |
| Charles Tillman | SHR | Left CB | 1 | 2 |
| Fred Robbins | BAL | Right Tackle | 1 | 2 |
| Shantee Orr | PHI | Left LB | 1 | 2 |
| Anthony Henry | NJG | Right CB | 1 | 2 |
| Gerald Hayes | SCO | Middle LB | 1 | 1 |
| Ben Leber | PHO | Left LB | 1 | 1 |
| Stuart Schweigert | STL | Free Safety | 1 | 1 |
| James Reed | BAC | Right Tackle | 1 | 0 |
| Casey Hampton | GBP | Nose Tackle | 1 | 0 |
| Jamal Williams | STL | Nose Tackle | 1 | 0 |
| Brian Simmons | PHS | Middle LB | 1 | 0 |
| Kindal Moorehead | HAM | Def Tackle | 1 | 0 |
| Robaire Smith | MIN | Left Tackle | 1 | 0 |
| Kyle Williams | SCS | Right Tackle | 1 | 0 |
| Sum | --- | --- | 575 | 3522 |
| Avg | --- | --- | 3 | 19 |