Player_Sacks
| NameFL | TAbb | PosN | Sack | SackYds |
| Rod Coleman | SF4 | Left Tackle | 12 | 69 |
| Jared Allen | SF4 | Right End | 9 | 69 |
| Joey Porter | SF4 | Right O LB | 9 | 65 |
| Adewale Ogunleye | PEO | Left End | 9 | 64 |
| Reggie Hayward | SF4 | Left End | 9 | 63 |
| Shaun Rogers | CAL | Left Tackle | 8 | 43 |
| Will Smith | SDC | Left End | 7 | 50 |
| Aaron Kampman | NOV | Left End | 7 | 31 |
| Michael Strahan | SEA | Left End | 6 | 48 |
| Dan Wilkinson | PHI | Right Tackle | 6 | 38 |
| Jordan Carstens | PHI | Right Tackle | 6 | 36 |
| Bertrand Berry | BAC | Right End | 6 | 32 |
| Lance Briggs | SF4 | Right LB | 5 | 47 |
| Leonard Little | FTW | Left End | 5 | 45 |
| Bryant Young | CAL | Left End | 5 | 41 |
| Julian Peterson | PEO | Left O LB | 5 | 41 |
| Aaron Schobel | HOU | Right End | 5 | 37 |
| Cullen Jenkins | SCS | Right Tackle | 5 | 35 |
| Mike Doss | SDC | Strong Safety | 5 | 33 |
| Derrick Burgess | HOU | Right End | 5 | 33 |
| Julius Peppers | FTW | Left End | 5 | 32 |
| Seth Payne | PHO | Nose Tackle | 5 | 28 |
| Adalius Thomas | OAK | Left LB | 5 | 28 |
| Jeremiah Trotter | SEA | Middle LB | 5 | 21 |
| Karlos Dansby | SDC | Left LB | 4 | 33 |
| Derrick Brooks | HOU | Right LB | 4 | 32 |
| Willie McGinest | NOV | Right O LB | 4 | 31 |
| Jermaine Phillips | SF4 | Strong Safety | 4 | 28 |
| Phillip Daniels | LAA | Right End | 4 | 25 |
| DeMarcus Ware | BAC | Right O LB | 4 | 24 |
| Marcus Stroud | BAC | Left Tackle | 4 | 23 |
| Chaun Thompson | PEO | Right O LB | 4 | 23 |
| Gibril Wilson | SEA | Strong Safety | 4 | 23 |
| Terrell Suggs | PHO | Right End | 4 | 22 |
| La'Roi Glover | NOV | Nose Tackle | 4 | 21 |
| Darwin Walker | BUF | Right Tackle | 4 | 11 |
| Nathan Vasher | SF4 | Right CB | 3 | 24 |
| Simeon Rice | NEP | Right End | 3 | 24 |
| Antwan Peek | PEO | Right O LB | 3 | 22 |
| John Henderson | FTW | Right Tackle | 3 | 21 |
| London Fletcher | HOU | Middle LB | 3 | 20 |
| Montae Reagor | SEA | Right Tackle | 3 | 19 |
| Tank Johnson | SDC | Def Tackle | 3 | 18 |
| Brian Urlacher | BAC | Middle LB | 3 | 17 |
| Shawne Merriman | HOU | Left O LB | 3 | 16 |
| Dexter Jackson | PHO | Free Safety | 3 | 12 |
| Paris Lenon | BUF | Left LB | 2 | 18 |
| Kevin Carter | BUF | Left End | 2 | 17 |
| Shaun Phillips | SDC | O LB | 2 | 16 |
| Jason Taylor | PHO | Right End | 2 | 16 |
| Steve Foley | PHI | Right O LB | 2 | 16 |
| D. Robertson | PEO | Left Tackle | 2 | 15 |
| Vince Wilfork | HOU | Nose Tackle | 2 | 14 |
| Akin Ayodele | NOV | Left LB | 2 | 13 |
| Travis LaBoy | PHI | Right End | 2 | 13 |
| John Abraham | PEO | Right End | 2 | 12 |
| Bob Sanders | FTW | Free Safety | 2 | 12 |
| Dwight Freeney | SCS | Right End | 2 | 12 |
| Orpheus Roye | SCS | Left End | 2 | 11 |
| Asante Samuel | PEO | Left CB | 2 | 10 |
| Grady Jackson | SDC | Left Tackle | 2 | 10 |
| Tedy Bruschi | NEP | Right I LB | 2 | 8 |
| Dan Morgan | PHO | Middle LB | 2 | 4 |
| Roy Williams | SF4 | Strong Safety | 2 | 4 |
| Keith Brooking | SCS | Middle LB | 2 | 0 |
| Derek Smith | FTW | Right I LB | 2 | 0 |
| Pat Williams | NEP | Left Tackle | 2 | 0 |
| Vonnie Holliday | NEP | Right Tackle | 1 | 12 |
| Sean Jones | SF4 | 1st Defensive Back | 1 | 12 |
| LeRoy Hill | BAC | Right LB | 1 | 11 |
| Tommie Harris | LAA | Left Tackle | 1 | 11 |
| Marquand Manuel | PEO | Free Safety | 1 | 10 |
| Champ Bailey | SEA | Left CB | 1 | 10 |
| John Thornton | BUF | Right Tackle | 1 | 9 |
| Kyle Vanden Bosch | BAC | Left End | 1 | 9 |
| Keith Bulluck | PHI | Right LB | 1 | 9 |
| Igor Olshansky | SDC | Right End | 1 | 8 |
| Bart Scott | PHO | Right LB | 1 | 8 |
| Adam Archuleta | HOU | Strong Safety | 1 | 8 |
| Donnie Edwards | SF4 | Left I LB | 1 | 8 |
| Jeff Posey | SEA | Left LB | 1 | 7 |
| Justin Miller | PHO | 1st Defensive Back | 1 | 7 |
| Kimo von Oelhoffen | BUF | Right End | 1 | 7 |
| Kindal Moorehead | NOV | Def Tackle | 1 | 7 |
| Bryce Fisher | CAL | Left End | 1 | 7 |
| Lance Schulters | NEP | Free Safety | 1 | 7 |
| Rob Meier | SEA | Def Tackle | 1 | 6 |
| Sam Madison | HOU | Right CB | 1 | 6 |
| Marcus Washington | SCS | Left LB | 1 | 5 |
| Greg Spires | LAA | Left End | 1 | 5 |
| Brian Dawkins | CAL | Free Safety | 1 | 5 |
| Dunta Robinson | PHO | Right CB | 1 | 5 |
| Will Witherspoon | FTW | Right LB | 1 | 5 |
| Patrick Kerney | NOV | Left End | 1 | 4 |
| Peter Sirmon | BUF | Left LB | 1 | 4 |
| Charles Grant | BAC | Right End | 1 | 4 |
| Quentin Jammer | FTW | Left CB | 1 | 4 |
| Al Singleton | SEA | Left O LB | 1 | 3 |
| Alex Brown | SCS | Right End | 1 | 3 |
| Kirk Morrison | PHO | Right LB | 1 | 2 |
| Kalimba Edwards | SDC | Def End | 1 | 2 |
| Odell Thurman | LAA | Middle LB | 1 | 0 |
| Albert Haynesworth | PEO | Right Tackle | 1 | 0 |
| Michael Myers | SDC | Left Tackle | 1 | 0 |
| Lofa Tatupu | OAK | Middle LB | 1 | 0 |
| James Farrior | PEO | Left I LB | 1 | 0 |
| Bradie James | BUF | Left I LB | 1 | 0 |
| Nick Barnett | NOV | Middle LB | 1 | 0 |
| Jonathan Vilma | NOV | Middle LB | 1 | 0 |
| Sum | --- | --- | 316 | 1969 |
| Avg | --- | --- | 3 | 18 |